Development of a Sustained-Release Voriconazole-Containing Thermogel for Subconjunctival Injection in Horses
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چکیده
منابع مشابه
Development of a Sustained-Release Voriconazole-Containing Thermogel for Subconjunctival Injection in Horses.
Purpose To determine in vitro release profiles, transcorneal permeation, and ocular injection characteristics of a voriconazole-containing thermogel suitable for injection into the subconjunctival space (SCS). Methods In vitro release rate of voriconazole (0.3% and 1.5%) from poly (DL-lactide-co-glycolide-b-ethylene glycol-b-DL-lactide-co-glycolide) (PLGA-PEG-PLGA) thermogel was determined fo...
متن کاملAdministering a subconjunctival injection
• Position the patient lying comfortably with his/her head supported on a pillow. • Reassure the patient that adequate anaesthetic drops will be instilled before the injection is given. • Instill anaesthetic drops at five-minute intervals over half an hour – a minimum of six drops. • Away from the patient’s view, draw up the prescribed medication using the 21G needle (Figure 1). • Change to the...
متن کاملParents’ views on their children’s use of eye drops and willingness to accept a new sustained-release subconjunctival injection
Aim The objectives of this study were to explore parents' views about their children's use of regular eye drops and whether they would consider a sustained-release subconjunctival injection as a replacement for daily drops. Methods A survey was conducted with 134 parents of children with chronic eye diseases at the Singapore National Eye Centre. Parents were asked their views about their chil...
متن کاملEvaluation of a Sustained-Release Prednisolone Acetate Biodegradable Subconjunctival Implant in a Non-Human Primate Model
PURPOSE We evaluate the toxicity and plasma toxicokinetic (TK) profile of a biodegradable subconjunctival microrod for sustained prednisolone acetate (PA) release over 12 weeks in a non-human primate model. METHODS The biodegradable copolymer poly(l-lactide-co-ε-caprolactone) (PLC) and 40-wt% PA microrods were used and fashioned into 8 and 16 mm lengths. Twelve monkeys were divided into two t...
متن کاملdevelopment and implementation of an optimized control strategy for induction machine in an electric vehicle
in the area of automotive engineering there is a tendency to more electrification of power train. in this work control of an induction machine for the application of electric vehicle is investigated. through the changing operating point of the machine, adapting the rotor magnetization current seems to be useful to increase the machines efficiency. in the literature there are many approaches wh...
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ژورنال
عنوان ژورنال: Investigative Opthalmology & Visual Science
سال: 2017
ISSN: 1552-5783
DOI: 10.1167/iovs.16-20899